Complex regional pain syndrome in children: a systematic review of clinical features and movement disorders.

Pain Manag. 2017 Mar;7(2):133-140. doi: 10.2217/pmt-2016-0036. Epub 2017 Feb 1

Abu-Arafeh H1,2, Abu-Arafeh I2.

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To ascertain clinical features of complex regional pain syndrome (CRPS) in children with a focus on movement disorders.


all publications with original data on children with CRPS were assessed. Data were tabulated and descriptive statistics were applied.


One population-based study and nine clinic-based studies provided data on demographic and clinical characteristics of childhood CRPS. Mean age of onset was 12.5 years and 85% of patients were females (risk ratio: 1.70; 95% CI: 1.54-1.88). History of trauma in 71% and the lower limbs were affected in 75% of patients. A secondary site involvement was present in 15%. Movement disorders and dystonia were reported in 30% of children.


Majority of cases of CRPS in children are females with mean age of 12.5 years. Movement disorders (mainly dystonia) affect at least one in three children with CRPS.

PMID: 28142335

DOI: 10.2217/pmt-2016-0036